Slow-Release Medicine

Medications designed to release their active ingredients gradually over an extended period, providing sustained therapeutic effects and reducing the frequency of dosing.

 

Extended-Release (ER):

A formulation of medication that allows for a prolonged and controlled release of the drug, maintaining therapeutic levels in the bloodstream over an extended period.

 

Time-Release:

Refers to the controlled and gradual release of a medication’s active ingredients over a specific time frame, ensuring a more consistent and sustained impact.

 

Pharmacokinetics:

The study of how the body processes medications, including absorption, distribution, metabolism, and excretion, crucial for designing slow-release formulations.

 

Bioavailability:

The proportion of a drug that enters the bloodstream and is available for the body to use, a critical factor in determining the effectiveness of slow-release medicines.

Peak Plasma Concentration:

The highest concentration of a drug in the bloodstream after administration, often lower and more prolonged with slow-release formulations.

 

Dosing Interval:

The time between each administration of a medication, with slow-release medicines typically allowing for less frequent dosing compared to immediate-release counterparts.

 

Matrix System:

A formulation technique where the active drug is embedded in a matrix or reservoir, controlling its release over time, commonly used in slow-release medications.

 

Gastrointestinal Transit Time:

The time it takes for a drug to travel through the digestive system, influencing the absorption and release characteristics of slow-release medicines.

Once-Daily Dosing:

A dosing regimen associated with slow-release medicines, allowing patients to take their medication only once a day due to the sustained release of active ingredients.

Therapeutic Window:

The range of drug concentrations in the bloodstream that provides the desired therapeutic effects without causing adverse reactions, often achieved more consistently with slow-release formulations.